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The antidepressant drug zyban is one of the newest and reportedly one of the most effective weapons in the anti-smoking arsenal.

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This medication should not be used if you are suddenly stopping regular use of sedativesincluding benzodiazepines such as lorazepamdrugs used to treat seizuresor alcoholDoing so may increase your risk of seizures.

Although not metabolised by the CYP2D6 isoenzymebupropion and its main metabolitehydroxybupropioninhibit the CYP2D6 pathwayCo-administration of bupropion hydrochloride and desipramine to healthy volunteers known to be extensive metabolisers of the CYP2D6 isoenzyme resulted in large2to 5-foldincreases in the C max and AUC of desipramineInhibition of CYP2D6 was present for at least 7 days after the last dose of bupropion hydrochloride.

Nicotineadministered transdermally by patchesdid not affect the pharmacokinetics of bupropion and its metabolites.

The list below provides information on the undesirable effects identified from clinical experiencecategorised by incidence and System Organ Class body systemIt is important to note that smoking cessation is often associated with nicotine withdrawal symptomse.gagitationinsomniatremorsweatingsome of which are also recognised as adverse events associated with Zyban.

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in the uk 66 people or their surviving families alleged zyban as being responsible for their problems which were cardio vascular, psychiatric or allergic.

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