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Nervous Systemencephalopathyconvulsiondizzinessneurotoxicity has been reported and manifested as reversible posterior leukoencephalopathy syndromemyelopathyperipheral neuropathypolyneuropathyneuralgiadysesthesiahypoesthesiaparesthesiatremordysgeusiahypogeusiaparosmia.

Increased hematotoxicity and/or immunosuppression may result from a combined effect of cyclophosphamide andfor exampleACE inhibitorsACE inhibitors can cause leukopeniaNatalizumab PaclitaxelIncreased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusionThiazide diuretics Zidovudine Increased cardiotoxicity may result from a combined effect of cyclophosphamide andfor exampleAnthracyclines Cytarabine Pentostatin Radiation therapy of the cardiac region Trastuzumab Increased pulmonary toxicity may result from a combined effect of cyclophosphamide andfor exampleAmiodarone G-CSFGM-CSFgranulocyte colony-stimulating factorgranulocytemacrophagecolony-stimulating factorReports suggest an increased risk of pulmonary toxicity in patients treated with cytotoxic chemotherapy that includes cyclophosphamide and G-CSF or GMCSFIncreased nephrotoxicity may result from a combined effect of cyclophosphamide andfor exampleAmphotericin B IndomethacinAcute water intoxication has been reported with concomitant use of indomethacin Increase in other toxicitiesAzathioprineIncreased risk of hepatotoxicityliver necrosisBusulfanIncreased incidence of hepatic veno-occlusive disease and mucositis has been reportedProtease inhibitorsIncreased incidence of mucositis Increased risk of hemorrhagic cystitis may result from a combined effect of cyclophosphamide and past or concomitant radiation treatment.

Cyclophosphamidealthough effective alone in susceptible malignanciesis more frequently used concurrently or sequentially with other antineoplastic drugs.

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