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More frequent side effects includediarrhea and nauseaSee below for a comprehensive list of adverse effects.

Taste pervasion most frequently occurred in patients given triple therapybut it was also very common in patients given quadruple therapyRef]

In a nonclinical study in Sprague-Dawley ratslifetime exposure24 monthsto oral pantoprazole at doses of 0.5 to 200 mg/kg/day resulted in dose-related increases in gastric ECL-cell proliferation and gastric neuroendocrineNEcell tumorsGastric NE-cell tumors in rats may result from chronic elevation of serum gastrin concentrationsThe high density of ECL cells in the rat stomach makes this species highly susceptible to the proliferative effects of elevated gastrin concentrations produced by PPIsHoweverthere were no observed elevations in serum gastrin following the administration of oral pantoprazole at a dose of 0.5 mg/kg/dayIn a separate studya gastric NE-cell tumor without concomitant ECL-cell proliferative changes was observed in 1 female rat following 12 months of dosing with oral pantoprazole at 5 mg/kg/day and a 9 month off-dose recoverysee Nonclinical Toxicology13.1

Read the Medication Guide provided by your pharmacist before you start taking pantoprazole and each time you get a refillIf you have any questionsask your doctor or pharmacist.

The following adverse reactions have been identified during postapproval use of Protonix and Protonix I.VBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

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