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Epidemiological studies showed that domperidone was associated with an increased risk of serious ventricular arrhythmias or sudden cardiac deathsee section 4.8A higher risk was observed in patients older than 60 yearspatients taking daily doses greater than 30 mgand patients concurrently taking QT-prolonging drugs or CYP3A4 inhibitors.

The main metabolic pathway of domperidone is through CYP3A4In vitro data suggest that the concomitant use of drugs that significantly inhibit this enzyme may result in increased plasma levels of domperidone.

If you have any questions or concerns about this issuespeak to your health professional.

The TGA is reviewing new information regarding domperidoneMotiliumand its potential effects on the patient’s heartparticularly with doses above 30 mg daily.

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