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If you are female, you will need to take a pregnancy test before you begin taking methotrexate.

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methotrexate should be used only by physicians whose knowledge and experience include the use of antimetabolite therapy.

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some studies have reported that adding leflunomide lef to the treatment of rheumatoid arthritis ra in patients who do not respond to methotrexate mtx improved efficacy but increased the risk of liver toxicity.

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your doctor may do regular tests to check how methotrexate tablets are affecting your body.

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