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Lipitor can cause a condition that results in the breakdown of skeletal muscle tissueleading to kidney failureThis condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidismunderactive thyroid

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in vitro studies suggest the importance of lipitor metabolism by cytochrome p450 3a4, consistent with increased plasma concentrations of lipitor in humans following co-administration with erythromycin, a known inhibitor of this isozyme see drug interactions 7.

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