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Baclofen drug can be administered either orally or intrathecally directly into the spinal fluid .

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Th was alsan incasd incidnc incomplt stnbal ossiication in tuss ats givn appoximatly 13 tims th maximum commndd human dos, and an incasd incidnc unossiid phalangal nucli olimbs and hindlimbs in tuss abbits givn appoximatly 7 tims th maximum commndd human dos. In mic, ntatognic cts w obsvd, although ductions in man tal wight with consqunt dlays in skltal ossiication w psnt whn dams w givn 17 and 34 tims th human daily dos. Th a nstudis in pgnant womn. Baclon should b usd duing pgnancy only i th bnit claly justiis th potntial isk tth tus.

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concomitant use with other substances which may induce hypotension as an adverse reaction like tricyclic antidepressants, antipsychotics, baclofen and amifostine may increase the risk of hypotension.

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