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HYDREA may damage spermatozoa and testicular tissueresulting in possible genetic abnormalitiesMales with female sexual partners of reproductive potential should use effective contraception during and after treatment with HYDREA for at least 1 year after therapysee Nonclinical Toxicology

As hydroxyurea is mainly eliminated from the body via the kidneysdose reductions may be necessary in patients with reduced kidney function.

Hydroxyurea passes into breast milk and may have undesirable effects on a nursing infantBreast-feeding while using this drug is not recommendedConsult your doctor before breast-feeding.

Hydroxyurea may cause other cancerssuch as secondary leukemiaskin cancerProtect your skin from the sunAvoid prolonged sun exposuretanning boothsand sunlampsUse sunscreen and wear protective clothing when outdoorsTell your doctor right away if you notice any symptoms of cancersuch as swollen glandssudden weight lossnight sweatsor unusual skin growths/moles.

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