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The target level for TSH suppression in these conditions has not been established with controlled studiesIn additionthe efficacy of TSH suppression for benign nodular disease is controversialThereforethe dose of SYNTHROID used for TSH suppression should be individualized based on the specific disease and the patient being treated.

Manufactured byAbbVie IncNorth ChicagoIL 60064U.S.A03-A663RevisedJune 2016.

Levothyroxine doses are based on weight in childrenYour dose needs may change if you gain or lose weight.

In womenlong-term levothyroxine sodium therapy has been associated with increased bone resorptionthereby decreasing bone mineral densityespecially in post-menopausal women on greater than replacement doses or in women who are receiving suppressive doses of levothyroxine sodiumThe increased bone resorption may be associated with increased serum levels and urinary excretion of calcium and phosphorouselevations in bone alkaline phosphatase and suppressed serum parathyroid hormone levelsThereforeit is recommended that patients receiving levothyroxine sodium be given the minimum dose necessary to achieve the desired clinical and biochemical response.

It may take several weeks before your body starts to respond to levothyroxineKeep using this medicine even if you feel wellYou may need to use levothyroxine for the rest of your life.

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