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To the best of our knowledge, this is the first case report of bupropion-induced mood shift when used specifically for nicotine cessation in a nonbipolar patient.

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Initial100 mg PO q12hrmay increase to 100 mg PO q8hr as early as day 4may consider increasing dose up to maximum 150 mg q8hr after several weeks if no clinical improvement observed with 100 mg q8hr Alternativelymay initiate with 75 mg PO q8hr.

No matter what your agebefore you take an antidepressantyouyour parentor your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatmentsYou should also talk about the risks and benefits of not treating your conditionYou should know that having depression or another mental illness greatly increases the risk that you will become suicidalespecially at the beginning of your treatment or any time that your dose is increased or decreasedThis risk is higher if you or anyone in your family has or has ever had bipolar disorder or mania or has thought about or attempted suicideTalk to your doctor about your conditionsymptomsand personal and family medical historyYou and your doctor will decide what type of treatment is right for you.

Report any new or worsening symptoms to your doctorsuch asmood or behavior changesanxietydepressionpanic attackstrouble sleepingor if you feel impulsiveirritableagitatedhostileaggressiverestlesshyperactivementally or physicallyor have thoughts about suicide or hurting yourself.

Drug ClassAntidepressantsOtherSmoking Cessation AidsAntidepressantsDopamine Reuptake Inhibitors.

Extended release tabletsAplenzinInitial dose174 mg orally once a day in the morningequivalent to 150 mg bupropion HClMaintenance doseAfter at least 4 daysthe dose may be increased to 348 mg once a dayequivalent to 300 mg bupropion HClIf there is not adequate improvement after several weeksthe dose may be increased to a maximum of 522 mg once a day in the morningequivalent to 450 mg bupropion HCl

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