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10 11 topical application of clindamycin phosphate can be used to treat mild to moderate acne.

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Clindamycin dosage modification may not be necessary in patients with renal diseaseIn patients with moderate to severe liver diseaseprolongation of clindamycin half-life has been foundHoweverit was postulated from studies that when given every eight hoursaccumulation should rarely occurThereforedosage modification in patients with liver disease may not be necessaryHoweverperiodic liver enzyme determinations should be made when treating patients with severe liver disease.

It is not known whether clindamycin will harm an unborn babyTell your doctor if you are pregnant or plan to become pregnant during treatment.

Pharmacokinetic studies in elderly volunteers61-79 yearsand younger adults18-39 yearsindicate that age alone does not alter clindamycin pharmacokineticsclearanceelimination half-lifevolume of distributionand area under the serum concentration-time curveafter IV administration of clindamycin phosphateAfter oral administration of clindamycin hydrochlorideelimination half-life is increased to approximately 4.0 hoursrange 3.4-5.1 hin the elderly compared to 3.2 hoursrange 2.14.2 hin younger adultsThe extent of absorptionhoweveris not different between age groups and no dosage alteration is necessary for the elderly with normal hepatic function and normalage-adjustedrenal function 1

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clindamycin is used to treat certain infections caused by bacteria.

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