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In female micecilostazol caused a reversible contraceptive effect at a dose300 mg/kgthat was approximately 7.4-fold greater than the Maximum Recommended Human DoseMRHDon a body surface area basisThese findings have not been demonstrated in other animal species.

Pletal reversibly inhibits platelet aggregation induced by a variety of stimuliincluding thrombinADPcollagenarachidonic acidepinephrineand shear stress.

The most frequent adverse reaction resulting in discontinuation of therapy in more than 3of patients treated with Pletal was headache50 mg twice daily1.3100 mg twice daily3.5and placebo0.3Other frequent causes of discontinuation included palpitation and diarrheaboth 1.1for Pletalall dosesversus 0.1for placebo.

Across the eight clinical trialsthe range of improvement in maximal walking distance in patients treated with Pletal 100 mg twice dailyexpressed as the change from baselinewas 28to 100

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