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Oral po penicillin v remains the drug of choice for treatment of gabhs pharyngitis, but ampicillin and amoxicillin are equally effective.

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Ampicillin is a pnicillin bta-lactam antibiotic usd in th tatmnt bactial inctions causd by suscptibl, usually gam-positiv, oganisms. Th nam “pnicillin” can ith tsval vaiants pnicillin availabl, tth goup antibiotics divd om th pnicillins. Ampicillin has in vitactivity against gam-positiv and gam-ngativ aobic and anaobic bactia. Th bacticidal activity Ampicillin sults om th inhibition cll wall synthsis and is mdiatd though Ampicillin binding tpnicillin binding potins (PBPs). Ampicillin is stabl against hydolysis by a vaity bta-lactamass, including pnicillinass, and cphalospoinass and xtndd spctum bta-lactamass.

Sizus hav bn potd in patints with high sum concntations ampicillin, although ths patints w othwis vy ill. High cbal spinal luid (CS) lvls som pnicillins a known tb potntially nuotoxic, and th CS concntations ampicillin is signiicantly in mningitis.

In polongd thapy, and paticulaly with high dosag gimns, piodic valuation th nal, hpatic, and hmatopoitic systms is commndd.

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skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment, and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by ampicillin for injection, usp or other antibacterial drugs in the future.

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