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Promethazine phenergan is similar in efficacy to ondansetron zofran , and oral methylprednisolone medrol is more effective than promethazine in the treatment of patients with hyperemesis gravidarum.

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Oral25 mg orally onceThis dose may be repeated every 4 hours as needed.

Oral or rectal12.5 mg before meals and 25 mg at bedtimeif necessaryAlternativelya single 25 mg dose given at bedtime or 6.25 mg to 12.5 mg three times dailyIM or IV25 mgmay repeat in 2 hours if necessary.

Treatment of overdosage is essentially symptomatic and supportiveOnly in cases of extreme overdosage or individual sensitivity do vital signsincluding respirationpulseblood pressuretemperatureand EKGneed to be monitoredActivated charcoal orally or by lavage may be givenor sodium or magnesium sulfate orally as a catharticAttention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilationDiazepam may be used to control convulsionsAcidosis and electrolyte losses should be correctedNote that any depressant effects of promethazine HCl are not reversed by naloxoneAvoid analeptics which may cause convulsions.

ANTIEMETICS ARE NOT RECOMMENDED FOR TREATMENT OF UNCOMPLICATED VOMITING IN PEDIATRIC PATIENTSAND THEIR USE SHOULD BE LIMITED TO PROLONGED VOMITING OF KNOWN ETIOLOGYTHE EXTRAPYRAMIDAL SYMPTOMS WHICH CAN OCCUR SECONDARY TO Phenergan TABLETS AND SUPPOSITORIES ADMINISTRATION MAY BE CONFUSED WITH THE CNS SIGNS OF UNDIAGNOSED PRIMARY DISEASEe.gENCEPHALOPATHY OR REYE’S SYNDROMETHE USE OF Phenergan TABLETS AND SUPPOSITORIES SHOULD BE AVOIDED IN PEDIATRIC PATIENTS WHOSE SIGNS AND SYMPTOMS MAY SUGGEST REYE’S SYNDROME OR OTHER HEPATIC DISEASES.

The average oral dose is 25 mg taken before retiringhowever12.5 mg may be taken before meals and on retiringif necessarySingle 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually sufficeAfter initiation of treatment in children or adultsdosage should be adjusted to the smallest amount adequate to relieve symptomsThe administration of promethazine HCl in 25-mg doses will control minor transfusion reactions of an allergic nature.

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